Transforming Tendon Care: From Diagnosis to Cure

Tendon injuries are clinically common, yet current care falls short. Conventional imaging fails to capture localized biochemical changes. Recovery is prolonged, with high re-rupture rates in large injuries and off-target effects. There is an urgent need for precise diagnostics and effective therapies.

• Microneedle bioelectronic chip: A porous microneedle sensor that monitors the biochemical environment at injury sites in real time, detecting specific biomarkers for objective quantitative diagnosis and long-term minimal-invasive monitoring.
• TendonMatrix scaffold: Derived from bovine tendon extracellular matrix using a proprietary process, our tendon matrix hydrogel-elastomer hybrid mimics the native tendon microenvironment with high bioactivity to promote tissue regeneration. It is formulated as a scaffold for increased mechanical support and can also be developed as an edible supplement for tendon healing.
• mRNA Therapy: Integrating precise local delivery, sustained release, and tendon-specific targeting, this approach demonstrates superior tendon regeneration in preclinical studies, far outperforming conventional treatments.

• As the first-in-field device for tendon disease diagnosis, the microneedle bioelectronic chip enables painless, precise grading, dynamic monitoring, and quantitative efficacy assessment, ushering tendon diagnostics into a new era of precision medicine.
• TendonMatrix scaffold:  Using advanced ECM extraction and optimized formulation, this highly bioactive mechanically robust scaffold mimics native tendon to promote rapid functional regeneration, reduce scarring, lower re-rupture risk, and accelerate recovery.
• Our tendon matrix hydrogel delivers TGF-β3 mRNA to precisely induce tendon differentiation and prevent ectopic bone formation. This overcomes the off-target risks of traditional growth factors, offering safer, more efficient, and higher-quality tendon healing.

• Silver Medal at the International Exhibition of Inventions, Geneva, 2025
• Gold medal with congratulations of the jury at the Aisa Exhibition of innovations and inventions, Hong Kong, 2025.

• Point-of-Care Testing: The porous microneedle can be used in clinics or sports medicine facilities to instantly assess the biochemical environment of an injury.
• Long-Term Monitoring: Enables physicians to track healing progress and adjust rehabilitation protocols based on objective data rather than just symptoms.
• Surgical & Injectable Applications: Hydrogel-assisted mRNA therapy and tendon matrix scaffold can be applied during surgical repair. The hydrogel can also be formulated as minimally invasive injection for non-surgical tendinopathy.
• Food Supplement: Oral formulation provides essential tendon components to support natural regeneration.