Multi-parameter prediction model for detection and management of liver cancer
Overview
The multi-parameter prediction model based on liquid biopsy could guide hepatocellular carcinoma (HCC) detection and clinical management. The model has good performance in early detection, disease monitoring, companion diagnostic tumor profiling and patient prognostication of HCC.
Commercialisation opportunities
Licensing
Problem addressed
There is no comprehensive examination of integrative genomic landscape of ctDNA and utilizing it in HCC. There is no practical guideline to advise procedures in adopting liquid biopsy for HCC detectiona and clinical management.
Innovation
- The multimodal genomic investigations include tumor mutation burden (the number of somatic mutations per 1Mb sequenced) in blood, somatic mutations, and hepatitis B virus genomic integrations, using the targeted-panel sequencing to examine ctDNA and delineate their holistic genomic landscape, which provide superior performance than considering individual hallmarks alone.
Key impact
- Translational applications of liquid biopsy allows early detection of HCC, which often presents at advanced stages and hence is inoperable.
- An noninvasive and promising approach for HCC disease monitoring and particularly useful when liver needle biopsy or repeated biopsy sampling is not feasible, as in HCC due to the risk of bleeding.
Application
- For HCC detection, disease monitoring and prognostication.
- As a measurement for HCC drug treatment efficacy.
Patent
- US provisional application
The University of Hong Kong (HKU)
Founded in 1911, The University of Hong Kong (HKU) is the first and oldest institution of higher education in Hong Kong. For over a century, the University has dedicated itself to creating knowledge, providing education, and serving society. Today, HKU has an established worldwide reputation for being a research-led comprehensive University with ten Faculties and a strong commitment to intellectual freedom, liberty and diversity. HKU has a proud record of academic recognition in researches through honours and awards received from both local and international bodies.
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