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A Microfluidic Biosensing System for Improved Cancer Diagnostics and Screening

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Overview

A portable microfluidic biosensing system for effective cancer diagnostic and screening. This is an advanced apparatus that captures targeted exosomes and allows detection by plasmonic biosensor for fast, high-sensitivity, high accuracy, and low-cost cancer screening.

  • A Microfluidic Biosensing System for Improved Cancer Diagnostics and Screening 0
  • A Microfluidic Biosensing System for Improved Cancer Diagnostics and Screening 1
  • A Microfluidic Biosensing System for Improved Cancer Diagnostics and Screening 2
Commercialisation opportunities
exclusive licensing
Problem addressed

A portable biosensing system for early cancer diagnostics and screening. It provides fast measurement with significantly improved sensitivity, convenient cancer screening, lower cost, and higher level of accuracy.

Innovation
  • A portable microfluidic biosensing system for detection of cancer at low concentration, with biosensor capable of trapping small size cancer markers and sensing small changes.
  • Nanometer-size cancer markers could be detected by the biosensor, while electrical force could be applied to increase trapping efficiency of cancer markers in order to increases detection sensitivity.
  • Fabrication technology, materials, and system design for the biosensing system to provide sensitive, low noise optical detection based on resonant peak shift.
Key impact
  • Low manufacturing and operating cost compared to existing apparatus that performs similar function.
  • More convenient to use, which is portable, small size, and with simpler setup.
  • Faster than existing apparatus, shorter time required to produce a result.
  • Low sample volume, which reduced sample volume from tens of ml to µl, while having high sensitivity to detect cancer at low concentration.
Award
  • Bronze Medal at Inventions Geneva Evaluation Days 2021
Application
  • Early stage cancer detection and diagnostic.
  • Convenience of use by medical practitioners as a portable system that can be used on daily applications that require point-of-care and low-cost setup.
  • Extendable to other disease screening as exosomes are shown to play essential role in health and disease indication.
  • Applicable to trapping and detection of various biomolecules for early disease diagnostic as this biosensor can monitor micrometer to nanometer size particles at low concentration.
City University of Hong Kong (CityU)

As one of the fastest growing universities in the world over the past decade, City University of Hong Kong (CityU) is recognised as a hub for innovation in research and professional education. CityU identifies solutions to critical global challenges by extending the frontiers of knowledge both within and beyond existing research paradigms.

The University’s highly qualified academics are drawn from all over the world, not only bringing a wealth of research and professional experience to the teaching programmes, but also contributing to the knowledge and technology advancement.

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