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Rapid Electrophoretic Purification of Nucleic Acids Through a Proprietary Artificial Biochip

HKUST
Overview

We have developed a biochip as a high-performance replacement to polymer gels in gel electrophoresis for rapid size-based separation of nucleic acids and proteins.

  • Rapid Electrophoretic Purification of Nucleic Acids Through a Proprietary Artificial Biochip
Commercialisation opportunities
Exclusive or non-exclusive licensing
Problem addressed

The important bottleneck in nucleic acid analysis is sample preparation. Our biochip can be utilized as an effective preparative tool for rapid purification of nucleic acids from contaminants. Some of these contaminants are challenging to remove through existing methods and yet known to inhibit or interfere with downstream analyses in PCR.

Innovation
  • Artificial biochip optimized for rapid (< 1 h) nucleic acid isolation and purification
  • Uncover crucial source of human genetic polymorphism for personalized and precision medicines
Key impact
  • Artificial sieve design optimized for rapid (< 1 h) electrophoretic focusing and purification of DNA.
  • Electrophoretic focusing and purification protocol optimized for maximum DNA yield and purity.
Application
  • Artificial biochip optimized for rapid (< 1 h) nucleic acid isolation and purification
  • Uncover crucial source of human genetic polymorphism for personalized and precision medicines

Patent

  • US Patent : US9937498B2
The Hong Kong University of Science and Technology (HKUST)

The Hong Kong University of Science and Technology (HKUST) (https://hkust.edu.hk/) is a world-class research intensive university that focuses on science, technology and business as well as humanities and social science. HKUST offers an international campus, and a holistic and interdisciplinary pedagogy to nurture well-rounded graduates with global vision, a strong entrepreneurial spirit and innovative thinking. Over 80% of our research work were rated “Internationally excellent” or “world leading” in the Research Assessment Exercise 2020 of Hong Kong’s University Grants Committee. We were ranked 3rd in Times Higher Education’s Young University Rankings 2022, and our graduates were ranked 23rd worldwide and among the best from universities from Asia in Global University Employability Survey 2021.

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