Growth Factor-free Proliferation & Differentiation of Stem Cell


This technology could generate healthy and functional cells for use in regenerative therapy, as well as treatment for neurodegenerative, chronic and joint diseases.

  • Growth Factor-free Proliferation & Differentiation of Stem Cell
Commercialisation opportunities
technology licensing agreement
Problem addressed

The conventional methods for cultivating stem cells typically require the use of animals and biochemical growth factors that may also encourage the growth of cancer cells. These methods are costly and the cells produced are often cancerous.

  • The device, called inorganic sculptured extracellular nanomatrices (iSECnMs), uses nanoscopic structures on its surfaces to stimulate growth and differentiation of stem cells by physical stimulation as well as inhibit other directors of differentiation.
  • Therefore, the device can substantially reduce the risk of inflammation or cancer cell formation. The material is biocompatible and low-cost, so the device is well-suited for mass production.
Key impact
  • This device can stimulate the growth and differentiation of stem cells by physical stimulation, while reducing the risk of inflammation or cancer cell formation arising from the stem cells from conventional methods using growth factors.
  • Controllable stem cell differentiation can be achieved
  • The device is suitable for mass production
  • Gold Medal with Congratulations of Jury at the 46th International Exhibition of Inventions of Geneva 2018
  • TechConnect Global Innovation Award 2019
  • Cell culture; Proliferation & Differentiation of stem cells
  • Stem cell therapy for neurodegenerative diseases, e.g. Parkinson’s disease and Alzheimer's disease


  • US Patent No. US 10,619,135
  • China Patent No. ZL 201780031011.8
  • European Patent No. EP3464568B1
Hong Kong Baptist University (HKBU)

Aspiring to be a leading, research-led, liberal arts University in Asia, Hong Kong Baptist University is committed to conducting world-leading investigations that extends the frontiers of knowledge, tackles global challenges and benefits the community at home and abroad. 

Pursuing research excellence is one of the priorities of the University’s Institutional Strategic Plan 2018-2028. The University keeps enhancing its capacity and strength to produce world-class research with an aim to bring significant impact to the society.