Dexamethasone exhibits therapeutic efficacies against various inflammatory conditions, including asthma, chronic obstructive pulmonary disease, and COVID-19. Its poor aqueous solubility however renders the bioavailability suboptimal. This invention showcases the rational design and characterization of hidden dexamethasone cocrystals possessing improved pharmaceutical properties, with an ultimate goal to facilitate an advanced drug delivery of a class of corticosteroids to benefit patients.
In attempt to salvage the clinical use of dexamethasone, this invention applies cocrystal engineering as a promising formulation technique for improving its pharmaceutical properties, including solubility and dissolution rate. The elusiveness of the dexamethasone cocrystal system was untangled by treatment of high temperature annealing, which functioned as an "on-off" control for the cocrystallization, coined "thermally activated cocrystallization".
Advanced Biomedical Instrumentation Centre
Biomedical instrumentation plays a critical and increasing role, albeit invisible to most people, in the healthcare industry by enabling more accurate diagnoses, effective treatments, and earlier intervention and prevention capabilities. Advancing the development of cutting-edge medical devices, actuators and sensors requires collaboration among talented scientists, engineers and clinicians, as well as an environment that facilitates the commercialisation of research results into real-world applications that are accessible to a broader population.
The mission of the Advanced Biomedical Instrumentation Centre is to accelerate progress in translating advanced biomedical instrumentation from research and development into real-world healthcare solutions that benefit people in Hong Kong and around the world. The Centre aims to foster collaboration among top-notch engineers, scientists and clinicians in the US and Hong Kong to develop next-generation microfluidics and low-cost instrumentation technologies. It also takes advantage of Hong Kong’ s vibrant start-up community to commercialise the research work tailored for Asian patients.