As mRNAs naturally degrades in the biological system, high-dose or repeated administration is commonly required. Our technology pioneered the engineering of artificial poly(A) tail sequences, via insertion of non-A nucleotides into the sequence, that can prolong mRNA half-life to effectively enhance protein expression rate and duration, with the effect being independent to transfection reagent, cell type, encoded protein, mRNA length.
The Hong Kong University of Science and Technology (HKUST) (https://hkust.edu.hk/) is a world-class research intensive university that focuses on science, technology and business as well as humanities and social science. HKUST offers an international campus, and a holistic and interdisciplinary pedagogy to nurture well-rounded graduates with global vision, a strong entrepreneurial spirit and innovative thinking. Over 80% of our research work were rated “Internationally excellent” or “world leading” in the Research Assessment Exercise 2020 of Hong Kong’s University Grants Committee. We were ranked 3rd in Times Higher Education’s Young University Rankings 2022, and our graduates were ranked 23rd worldwide and among the best from universities from Asia in Global University Employability Survey 2021.