Long-lasting Spexin Could Spell the End of Obesity

Overview

The present invention is a newly synthesized spexin cyclic analogues that have much longer half-lives in serum. An intravenous injection of these analogues in obese mice resulted in reduced food intake and weight loss with few side effects.

  • Long-lasting Spexin Could Spell the End of Obesity 0
  • Long-lasting Spexin Could Spell the End of Obesity 1
  • Long-lasting Spexin Could Spell the End of Obesity 2
Commercialisation opportunities
technology licensing agreement
Problem addressed

Some researchers have suggested that the administration of spexin (a neuropeptide) may promote weight loss in humans. However, the neuropeptide has had limited success due to its short half-life in serum (i.e., it leaves the body too quickly). Our synthesized spexin cyclic analogues have much longer half-lives in serum, and this may address the concern.

Innovation
  • Our synthesized spexin cyclic analogues have much longer half-livesin serum, meaning that it won'tleave the body too quickly.
  • In our animal study, it has proved that the analogues are very effective as it can reduce food intake and promote weight loss with much lower side effects when comparing to other drugs.
Key impact
  • Since these spexin cyclic analogues can stay longer in the body, the frequency of drug intakes or even the dosage might be significantly reduced that can benefit the user.
Application
  • The present invention can bepotentially used for treatingseveral metabolic diseases including type-II diabetes, non-alcoholic fatty liver disease and, most notably, obesity.
Hong Kong Baptist University (HKBU)

Aspiring to be a leading, research-led, liberal arts University in Asia, Hong Kong Baptist University is committed to conducting world-leading investigations that extends the frontiers of knowledge, tackles global challenges and benefits the community at home and abroad. 

Pursuing research excellence is one of the priorities of the University’s Institutional Strategic Plan 2018-2028. The University keeps enhancing its capacity and strength to produce world-class research with an aim to bring significant impact to the society. 

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