In this invention, we conjugated pseudaminic acid which is the surface glycan of A. baumannii to a carrier protein CRM197. The resulted conjugation worked as a bacteria vaccine which could stimulate high immune responses in mice and protected the vaccinated mice from infections caused by Pseproducing A. baumannii.
Acinetobacter baumannii was listed as “priority pathogens" by the World Health Organization (WHO) due to its multidrug-resistance. It is lack of effective drugs for treating acinetobacter baumannii infection.
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