Broad Spectrum Anti-viral Peptides

HKU
Overview

A series of broad spectrum antiviral peptides and composition including therapeutically effective amounts of the antiviral peptides along with a pharmaceutically acceptable carrier were developed. The antiviral compositions show a strong broad spectrum antiviral effect without resulting to viral resistance. These antiviral peptides are effective in treating diseases caused by viral infections, particularly respiratory viruses.

  • Broad Spectrum Anti-viral Peptides 0
  • Broad Spectrum Anti-viral Peptides 1
Technical name of innovation
Broad Spectrum Anti-viral Peptides
Commercialisation opportunities
Licensing, collaboration
Problem addressed

Viral infection annually still causes millions of deaths globally. Taking Influenza virus as an example, annually causes over 3 to 5 million cases of severe illness with about 0.25 million deaths globally. In addition, resistance was found in most of current anti-viral drugs so it is essential to develop a new broad spectrum anti-viral drug.

Innovation
  • The duo function anti-viral peptides provide effective and broad-spectrum of anti-viral effect by blocking viral entry and preventing the viral replication through inhibiting the endosomal acidification
  • The studies indicated that there is low possibility of inducing drug-resistance viruses
  • The metabolic toxicity for the peptides is low and did not induce significant change of body weight in the animal model
Key impact
  • The duo function peptides provide effective and broad-spectrum of anti-viral effect to Influenza A, influenza B and SARS-CoV-2
  • Low possibility of inducing drug-resistance viruses
  • Low metabolic toxicity for these anti-viral peptides in the animal model
Application
  • Broad-spectrum antiviral agent, particular to those pH-dependent viruses such as influenza A, influenza B, SARS-CoV

Patent

  • EP Application No. 19792753.6; US Application No. 17/049,974; PRC Application No. 201980028519.1
  • PCT Application No. PCT/CN2021/078639   PCT Application No. PCT/CN2021/125649
  • PCT Application No. PCT/CN2022/076453
The University of Hong Kong (HKU)

Founded in 1911, The University of Hong Kong (HKU) is the first and oldest institution of higher education in Hong Kong. For over a century, the University has dedicated itself to creating knowledge, providing education, and serving society. Today, HKU has an established worldwide reputation for being a research-led comprehensive University with ten Faculties and a strong commitment to intellectual freedom, liberty and diversity. HKU has a proud record of academic recognition in researches through honours and awards received from both local and international bodies.

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