Adiponectin is a key regulator of glucose and lipid metabolism. A decrease in the production of adiponectin is involved in the pathogenesis of insulin resistance, type 2 diabetes, steatohepatitis, cardiovascular diseases, and certain types of cancers. However, adiponectin-based therapeutics are not possible at present, mainly due to the difficulty in obtaining the full-length glycosylated human adiponectin.
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