ProEGCG: A Prodrug to Relieve Menstrual Discomfort and Prevent Endometriosis
Overview
ProEGCG, is a novel derivative of epigallocatechin-3-gallate (EGCG) derived from green tea. This non-hormonal supplement is designed to alleviate the menstrual discomfort and prevent endometriosis. ProEGCG enhances the bioavailability and stability of EGCG, leading to more effective therapeutic outcomes, and brings no hormonal side effect and safer to reproductive functions.
Technical name of innovation
ProEGCG
Commercialisation opportunities
We collaborate with gynaecologists and healthcare providers to position ProEGCG as a trusted option.
Problem addressed
Our previous publications show that ProEGCG has stronger anti-angiogenic and anti-inflammatory properties than EGCG, making it beneficial for menstrual discomfort and endometriosis. ProEGCG demonstrates a sustainable therapeutic effect with reduced side effects on reproductive functions, as compared to current treatment.
Innovation
- Unlike traditional treatments that suppress sex hormones and may lead to undesirable side effects, we leverage naturally derived compounds, allowing for continuous use with improved efficacy and minimized side effects, including those related to jeopardising reproductive functions.
- ProEGCG works by inhibiting neovascularization, cell growth in lesions, and inflammatory responses without interfering with sex hormones.
Key impact
- ProEGCG as an effective durg for alleviating pain and managing endometriosis will lead to an improved quality of life for affected women. Women will be able to engage fully in daily activities, work, and social interactions, thereby reducing physical, emotional, and financial burdens. This will contribute to better reproductive health and family planning outcomes.
- Healthcare professionals and researchers in the field will be equipped with better support patients with endometriosis and menstrual pain. They will be better positioned to implement effective management strategies, resulting in improved patient care.
- Green tea’s huge potential suggests that ProEGCG can be utilized in other health products, medical products, or recreational products. EGCG is associated with various health benefits, including treating cancer, weight management, and mental well-being. Our research group demonstrated that ProEGCG is effective in combating uterine fibroids and endometrial cancer.
Award
- Awared Gold Medal at Silicon Valley International Invention Festival 2024 with project: ProEGCG: A Prodrug to Relieve Menstrual Discomfort and Prevent Endometriosis - Gene Man Chi-wai, Sze Wan Hung, Loucia Chan Kit-ying, Zhang Tao, Liona Poon Chiu-yee, Ronald Wang Chi Chiu
- Awared Silver Medal at International Exhibition of Inventions Geneva 2024 with project: ProEGCG: Prodrug for safe and effective treatment of endometrial cancer - Gene Man Chi-wai, Loucia Chan Kit-ying, Zhang Tao, Liona Poon Chiu-yee, Ronald Wang Chi Chiu
- Awared Silver Medal at International Exhibition of Inventions Geneva 2022 Silver Medal, ProEGCG for Treatment of Endometriosis - Chi Chiu Wang, Chi Wai Man, Sze Wan Hung, Xiaoyan Chen
Application
- Women of all ages who seek effective and safe solutions for gynaecological health issues including but not limited to menstrual pain and discomfort from endometriosis.
- Women who seek natural and effective supplements for gynaecological health, which can be conveniently purchased over the counter.
Patent
- We have obtained China and US patent for the application of ProEGCG for endometriosis treatment.
The Chinese University of Hong Kong (CUHK)
Founded in 1963, The Chinese University of Hong Kong (CUHK) is a forward-looking comprehensive research university with a global vision and a mission to combine tradition with modernity, and to bring together China and the West. CUHK teachers and students hail from all around the world. Four Nobel laureates are associated with the university, and it is the only tertiary institution in Hong Kong with recipients of the Nobel Prize, Turing Award, Fields Medal and Veblen Prize sitting as faculty in residence. CUHK graduates are connected worldwide through an extensive alumni network. CUHK undertakes a wide range of research programmes in many subject areas, and strives to provide scope for all academic staff to undertake consultancy and collaborative projects with industry.
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