Biomimicking Photocrosslinkable Nanocomposite Bone Graft

Overview

PolyU has developed novel photocrosslinkable nanocomposite bone graft to mimic the natural bone. The low temperature and organic solvent-free fabrication process allows it to encapsulate bioactive molecules for long-term release. It can activate cell signaling pathways to simultaneously promote osteogenesis and angiogenesis while providing optimal mechanical support to the injured area, expediting the healing process. This technology has been commercialised through PolyU academic-led start-up Bonejoy Limited.

  • Biomimicking Photocrosslinkable Nanocomposite Bone Graft 0
  • Biomimicking Photocrosslinkable Nanocomposite Bone Graft 1
  • Biomimicking Photocrosslinkable Nanocomposite Bone Graft 2
Commercialisation opportunities
IP licensing, Collaboration for product development, technology development in various application segments; Product distribution
Problem addressed

To balance the processability, mechanical strength and bioactivity of bone graft materials, PolyU has developed photocrosslinkable nanocomposite bone graft as an affordable and effective alternative to the growing market and serve patients who are receiving orthopedic surgeries. It has high bone regeneration potential, involves simple and green fabrication processes, and incurs low material costs.

Innovation
  • The novel photocrosslinkable nanocomposite mimics natural bone structure with high processability for personalized treatments.
  • The nanocomposite bone graft can be fabricated within 140 seconds under light exposure at 36°C, allowing it to load, preserve and perform long-term release of bioactive molecules to accelerate bone regeneration.
  • The nanocomposite bone graft can activate cell signaling pathways to simultaneously promote osteogenesis and angiogenesis, expediting the healing process.
Key impact
  • Injectable and 3D printable - can be premade, trimmed and directly applied during bone graft operations according to the patients’ needs.
  • Strong and bioactive - provides optimal mechanical support and allows encapsulation and long-term release of bioactive molecules.
  • Osteogenic and angiogenic - activates cell signaling pathways for enhanced bone regeneration and vascularization.
  • Biodegradable, metabolizable and biocompatible – all components can be metabolized in the human body.
Award
  • Silver Medal - Special Edition 2021 Inventions Geneva Evaluation Days - Virtual Event (Mar 2021)
  • PolyU Micro Fund 2020
Application
  • Bone scaffold
  • Artificial periosteum
The Hong Kong Polytechnic University (PolyU)

With over 80 years of proud tradition and ranking among the world’s top 100 institutions, The Hong Kong Polytechnic University (PolyU) aspires to be a leading university with world-class research and education.

PolyU is a home for educating thinkers, discoverers, innovators and communicators in delivering positive impact. We are committed to nurturing tomorrow’s leaders today, through a holistic education that provides graduates unrivaled placements to thrive in communities, industries and businesses.

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