Biomimicking Photocrosslinkable Nanocomposite Bone Graft

To balance the processability, mechanical strength and bioactivity of bone graft materials, PolyU has developed photocrosslinkable nanocomposite bone graft as an affordable and effective alternative to the growing market and serve patients who are receiving orthopedic surgeries. It has high bone regeneration potential, involves simple and green fabrication processes, and incurs low material costs.

• The novel photocrosslinkable nanocomposite mimics natural bone structure with high processability for personalized treatments.
• The nanocomposite bone graft can be fabricated within 140 seconds under light exposure at 36°C, allowing it to load, preserve and perform long-term release of bioactive molecules to accelerate bone regeneration.
• The nanocomposite bone graft can activate cell signaling pathways to simultaneously promote osteogenesis and angiogenesis, expediting the healing process.

• Injectable and 3D printable - can be premade, trimmed and directly applied during bone graft operations according to the patients’ needs.
• Strong and bioactive - provides optimal mechanical support and allows encapsulation and long-term release of bioactive molecules.
• Osteogenic and angiogenic - activates cell signaling pathways for enhanced bone regeneration and vascularization.
• Biodegradable, metabolizable and biocompatible – all components can be metabolized in the human body.

• Silver Medal - Special Edition 2021 Inventions Geneva Evaluation Days - Virtual Event (Mar 2021)
• PolyU Micro Fund 2020

• Bone scaffold
• Artificial periosteum

• A preparation method of photocrosslinkable nanocomposite and bone tissue engineering scaffolds (China, granted, 201911078331.6）
• Preparation and application of periosteum mimicking nanocomposite materials (China, filed, 201911080184.6)
• Preparation and application of an adhesive artificial periosteum (China, filed, 202210360549.6)