CityU developed a real-time hardware programmable gate array (FPGA)-based cerebellum stimulator prototype to detect and restore abnormal gait cycle based on electromyography activities of muscles. Close-loop cerebellum stimulator is triggered only when an abnormal gait cycle is detected to avoid excessive stimulation results in side effects as compared with traditional deep brain stimulation that produces continuous stimulation to patients.
Currently used DBS systems are open-loop devices that produce continuous stimulation regardless of fluctuations in the disease state, leading to adverse side effect. It also reduces battery lifetime of stimulators results in increasing the frequency of replacement surgery. Therefore, our designed closed-loop DBS aimed to reverse side effects of continuous stimulation and increase the battery durability of stimulator.
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