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A universal quantitative method for a panel of cytokines using ion mobility mass spectrometry

Overview

This invention relates to development of a cytokine peptide database designed to create a universal quantitative method for cytokines using ion mobility mass spectrometry (IM-MS). This database and associated methods aim to improve the identification, quantification, and analysis of cytokines for medical and clinical applications, particularly in immunotherapy and disease monitoring.

  • A universal quantitative method for a panel of cytokines using ion mobility mass spectrometry 0
Commercialisation opportunities
Non-exclusive licensing
Problem addressed

The invention addresses challenges in cytokine research and clinical applications by integrating multidimensional data into a comprehensive peptide database.

Innovation
  • The invention focuses on constructing a cytokine peptide database based on ion mobility mass spectrometry for universal cytokine quantification.
  • It uses of collision cross-sectional area (CCS) as a standardized parameter for more precise peptide separation and quantification. 
Key impact
  • The database and method enable precise quantification of inflammation-related cytokines, such as endothelin-1, in clinical settings.
  • The CCS values being intrinsic properties of ions make the database portable across different instruments.
Application
  • This invention can be developed for clinical applications, such as early detection of Cytokine storms and supports personalized immunotherapy by tracking cytokine dynamics in cancer treatment.

Patent

  • China Patent Publication No.: CN118298934A
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