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A universal quantitative method for a panel of cytokines using ion mobility mass spectrometry

Overview

This invention relates to development of a cytokine peptide database designed to create a universal quantitative method for cytokines using ion mobility mass spectrometry (IM-MS). This database and associated methods aim to improve the identification, quantification, and analysis of cytokines for medical and clinical applications, particularly in immunotherapy and disease monitoring.

  • A universal quantitative method for a panel of cytokines using ion mobility mass spectrometry 0
Commercialisation opportunities
Non-exclusive licensing
Problem addressed

The invention addresses challenges in cytokine research and clinical applications by integrating multidimensional data into a comprehensive peptide database.

Innovation
  • The invention focuses on constructing a cytokine peptide database based on ion mobility mass spectrometry for universal cytokine quantification.
  • It uses of collision cross-sectional area (CCS) as a standardized parameter for more precise peptide separation and quantification. 
Key impact
  • The database and method enable precise quantification of inflammation-related cytokines, such as endothelin-1, in clinical settings.
  • The CCS values being intrinsic properties of ions make the database portable across different instruments.
Application
  • This invention can be developed for clinical applications, such as early detection of Cytokine storms and supports personalized immunotherapy by tracking cytokine dynamics in cancer treatment.

Patent

  • China Patent Publication No.: CN118298934A
Hong Kong Baptist University (HKBU)

Aspiring to be a leading, research-led, liberal arts University in Asia, Hong Kong Baptist University is committed to conducting world-leading investigations that extends the frontiers of knowledge, tackles global challenges and benefits the community at home and abroad. 

Pursuing research excellence is one of the priorities of the University’s Institutional Strategic Plan 2018-2028. The University keeps enhancing its capacity and strength to produce world-class research with an aim to bring significant impact to the society. 

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