Screening and analyzing method of p-phenylenediamine quinone substance and application thereof
Overview
HKBU has developed a method which employs high-resolution mass spectrometry (HRMS) combined with multi-strategy screening techniques to identify both known and unknown PPD-quinone compounds in various environmental media.
Commercialisation opportunities
Non-exclusive licensing
Problem addressed
This method addresses challenges such as the lack of commercial standards and the need for high specificity and reduced false positives.
Innovation
- This method combines full scanning, full-ion fragmentation scanning (AIF), and neutral loss secondary mass spectrum scanning (NL dd-MS2) for comprehensive screening.
- Specific diagnostic ions and neutral loss fragments are used as markers to screen PPD-quinones, ensuring high specificity and reduced false positives.
- This approach includes steps like sample pre-treatment, HRMS analysis, and software-based data extraction and filtering.
Key impact
- It provides a high efficiency, specificity, and applicability in identifying PPD-quinones in soil, air, and tire samples, providing critical insights into their environmental presence and potential health impacts.
- This approach is highly efficient, specific, and capable of reducing false positives, offering a significant advancement in the detection and characterization of emerging contaminants.
Application
- The current invention can be developed to screen for both known and unknown compounds for environmental monitoring and identifying new contaminants.
Patent
- China Patent Publication No.: CN 118348132 A
